Figure 2.

Effects of CoPP on PTX-induced mechanical and cold allodynia. Mechanical (A: left paws; B: right paws) and cold (C: left paws; D: right paws) antiallodynic effects produced by the repeated administration of 5 mg/kg of CoPP or vehicle for five days from days 17 to 21 after PTX injection. In all panels, for each day and treatment evaluated, * indicates significant differences vs. the vehicle–vehicle-treated animals and + vs. PTX–vehicle-treated animals (p < 0.05, one-way ANOVA followed by the SNK test). Results are shown as mean values ± SEM; n = 6 animals per experimental group.