Effects of treatment with CoPP on the emotional behavioral disorders associated with PTX-induced neuropathic pain. Effects of the repetitive administration of 5 mg/kg of CoPP or vehicle from days 17 to 21 after PTX or vehicle (VEHI) injection on the anxiety- (EPM and OF tests) and depressive-like behaviors (TST and FST) associated with CIPN. In the EPM test, the number of times that animals entered the open arms (A), the percentage of total time spent in open arms (B), and the number of entrances into the closed arms (C) are represented. In the OF test, the number of entries into the central area (E), the percentage of time spent within the central area (F), and the total number of squares crossed (G) are shown. Figures (D,H) display the time the animals spent in immobility (s) in the TST (D) and FST (H). In all panels, * indicates significant differences vs. the vehicle–vehicle-treated animals; &, vs. the vehicle–CoPP-treated animals; and $, vs. the animals treated with PTX plus CoPP (p < 0.05, one-way ANOVA followed by the SNK test). Data are expressed as mean values ± SEM; n = 8 animals per experimental group.