Figure 4.

Effects of GYY4137 on PTX-induced nociception. Mechanical (A: left paws; B: right paws) and cold (C: left paws; D: right paws) antiallodynic effects produced by the repeated administration of 35 mg/kg of GYY4137 or vehicle for four days from days 18 to 21 after PTX injection. In all graphs, for each day and treatment evaluated, * indicates significant differences vs. the vehicle–vehicle-treated animals, and +, vs. the PTX–vehicle-treated animals (p < 0.05, one-way ANOVA followed by the SNK test). Results are shown as mean values ± SEM; n = 6 animals per experimental group.