Effects of CoPP and GYY4137 on the expression of p-P38, p-ERK 1/2, PI3K, and p-Akt in the DRG of PTX-injected mice. The graphs represent the protein levels of p-P38/P38 (A), p-ERK 1/2/ERK 1/2 (B), PI3K (D), and p-Akt/Akt (E) in the DRG of PTX-injected mice treated with CoPP or GYY4137. The control group treated with VEHI–VEHI is also shown. Representative blots for p-P38, P38, p-ERK 1/2, and ERK 1/2 (C) and for PI3K, β-actin, p-Akt, and Akt (F) are displayed. In all panels, * indicates significant differences vs. the VEHI–VEHI-treated mice, and $, vs. PTX-injected mice treated with GYY4137 (p < 0.05, one-way ANOVA followed by the SNK post hoc test). Data are expressed as mean values ± SEM; n = 3 samples per group.