Table 4.

Overview of effects of ghrelin in experimental epilepsy models. i.c.v.: intracerebroventricular; i.h.: intrahippocampal; IHKA: intrahippocampal kainic acid; i.p.: intraperitoneal; KA: kainic acid; min: minute; pen: penicillin; pilo: pilocarpine; PTZ: pentylenetetrazole; Ref: reference.

Dose	Administration Regimen	Anticonvulsant	Animal Model	Ref
0.02–0.08 mg/kg	i.p. 30 min prior to PTZ	yes	PTZ i.p. rat model	[105,117]
0.08 mg/kg	i.p. 30 min prior to PTZ	no	PTZ i.p. rat model	[118]
0.3 nmol/µL	i.h. infusion 1 x 30 min prior to PTZ or 10 days	yes	PTZ i.p. rat model	[106,107]
0.08 mg/kg	i.c.v. 30 min prior to PTZ	yes	PTZ i.p. rat model (female rats)	[108]
0.5, 1 and 2 µg	i.c.v. 30 min after pen	yes	Intracortical penicillin rat model	[113,119]
0.08 mg/kg	i.p., immediate assessment	no	WAG/Rij rat model	[114]
0.01–10 µM	i.h. infusion, 120 min prior to pilo	yes	Pilocarpine i.h. infusion rat model	[116]
1.5 mg/kg	i.p. 10 min prior to pilo	no	Pilocarpine i.p. rat model	[31,115]
1.5 mg/kg	i.p. 10 min prior to KA	no	KA i.p. rat model	[115]
0.08 mg/kg	i.p. 30 min prior to KA, and 24 h after KA	yes	KA i.p. mouse model	[29]
1.8 mg/kg	i.p. 30 min prior to pilo	yes	Pilocarpine tail infusion mouse model	[116]