Table 5.
Overview of effects of desacyl ghrelin in experimental epilepsy models. i.c.v.: intracerebroventricular; i.p.: intraperitoneal; KA: kainic acid; min: minute; pilo: pilocarpine; Ref: reference.
| Desacyl Ghrelin | ||||
|---|---|---|---|---|
| Dose | Administration Regimen |
Anticonvulsant | Animal Model | Ref |
| 1.5 mg/kg | i.p. 10 min prior to pilo |
yes/no (p = 0.07) |
Pilocarpine i.p. rat model |
[115] |
| 1.5 mg/kg | i.p. 10 min prior to KA |
yes | KA i.p. rat model |
[115] |
| 1–10 µM | i.c.v. 2 h prior to pilo |
yes | Pilocarpine i.c.v. rat model | [37] |
| 3/5 mg/kg | i.p. 30 min prior to pilo |
yes | Pilocarpine tail infusion mouse model | [37] |