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. 2022 Jan 5;11(1):77. doi: 10.3390/biology11010077

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic representation of the long and short forms of human Alsin. According to homology modelling, four structured domains, numbered according to the Uniprot Q96Q42 entry, were predicted in human Alsin, namely the RLD (RCC1-like domain), DH-PH (Dbl homology-pleckstrin homology), MORN (membrane occupation and recognition nexus), and VPS9 (vacuolar protein-sorting 9) domains. We used representative structures of these domains (PDB entries 1A12, 2Z0Q, 6T4D, and 2OT3) to illustrate the 3D folds that the RLD, DH-PH, MORN, and VPS9 domains predicted in human Alsin, respectively, may adopt. Structured domains are shown as ribbons with the same color code as the one utilized for the sequence schematic representation.