Figure 2.

Possible biotransformation of PIP metabolites in hepatocyte. Based on Li Y et al. [28], 20 metabolites could be detected from PIP in the liver. Li and colleagues used hepatocytes of four different species (human, rat, mouse, and dog) and found that a few of these 20 metabolites could be detected in all species (C6, C9, C11, C12, C13, C14, C15, C19, and C20), but not all. C1–5, C7, and C17 were found to be present in both mouse and rat species, while C10, C16, and C18 were exclusively present in mouse. Metabolite C8 was observed only in rat hepatocyte. Other than common metabolites for all species, C7 in human and C2–5 in dog hepatocytes were observed.