Table 3.
Clinical trial data of some Essential oils.
| Sr. No. | Study Title | Condition | Interventions | Study Design | Phase | Location | Status | Outcome Measurement | Reference | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1. | Effect of a Medicated Topical Therapy, Petrolatum, and No Treatment on Nocturnal Cough | Respiratory tract Diseases | Other: Ointment containing camphor, eucalyptus oil, and menthol One time use Other: Petroleum jelly One time use |
Study Type: | Interventional (Clinical Trial) | - | United States, Pennsylvania | Complete | Subjective assessment of cough and congestion symptoms (Time Frame: 24 h) | [88] |
| Actual Enrollment: | 143 participants | |||||||||
| Allocation: | Randomized | |||||||||
| Intervention Model: | Parallel Assignment | |||||||||
| Masking: | Double (Participant, Investigator) | |||||||||
| Primary Purpose: | Treatment | |||||||||
| 2. | Treatment of Acute Rhino-Sinusitis with Essential Oils of Aromatic Plants | Rhino-Sinusitis | Dietary Supplement: mixture of aromatic essential oils. 1% of mixture containing aromatic essential oils of Eucalyptus citriodora, Eucalyptus globulus, Mentha piperita, Origanum syriacum, and Rosmarinus Officinalis, spraying to the nose. Dietary Supplement: placebo 0.1% of Lemon VIP (Florasynth, Israel), spraying to the nose. |
Study Type: | Interventional (Clinical Trial) | I and II | Israel | Complete | To demonstrate a relief in the nasal obstruction within the first 20 min after first administration of treatment with the spray. (Time Frame: 20 min) To demonstrate a reduction in a defined symptoms sum score based on symptoms and signs comparing baseline therapy from the beginning to the end of 3 days treatment. (Time Frame: 3 days) |
[89] |
| Actual Enrollment: | 14 participants | |||||||||
| Allocation: | Randomized | |||||||||
| Intervention Model: | Parallel Assignment | |||||||||
| Masking: | Double (Participant, Investigator) | |||||||||
| Primary Purpose: | Treatment | |||||||||
| 3. | Treatment of Acute Tracheitis and Laryngitis With Essential Oils of Aromatic Plants | Viral Laryngitis Viral Tracheitis |
Dietary Supplement: mixture of aromatic essential oils. 3% of mixture containing aromatic essential oils of Eucalyptus citriodora, Eucalyptus globulus, Mentha piperita, Origanum syriacum, and Rosmarinus Officinalis, spraying to the larynx. Dietary Supplement: placebo 0.1% of Lemon VIP (Florasynth, Israel), spraying to the larynx |
Study Type: | Interventional (Clinical Trial) | I and II | Israel | complete | To demonstrate a cough or hoarseness relief within the first 20 min after first administration of treatment with the spray. (Time Frame: 20 min) To demonstrate a reduction in a defined symptoms sum score based on symptoms and signs comparing baseline therapy from the beginning to the end of 3 days treatment. (Time Frame: 3 days) |
[90] |
| Actual Enrollment: | 29 participants | |||||||||
| Allocation: | Randomized | |||||||||
| Intervention Model: | Parallel Assignment | |||||||||
| Masking: | Double (Participant, Investigator) | |||||||||
| Primary Purpose: | Treatment | |||||||||
| 4. | Anosmia Rehabilitation in Patients Post Coronavirus Disease (COVID 19) | Olfactory Disorder | Other: Olfactory retraining Olfactory retraining Olfactory training is performed by exposing patients twice daily to essential oils with four specific odors, present in glass jars with soaked cotton pads: phenyl ethyl alcohol, rose; eucalyptol, eucalyptus; citronellal, lemon; eugenol, cloves. Drug: corticosteroid nasal irrigation Other: smell household Items Other: Nasal Irrigation |
Study Type: | Interventional (Clinical Trial) | IV | Canada, Ontario | With-drawn | Change from Baseline Snap and Sniff Threshold Test and Smell Identification Test (SIT) at 3 months (Time Frame: 3 and 6 months) Score from the Snap and Sniff Olfactory Test results and Smell Identification test results. |
[91] |
| Actual Enrollment: | 0 participants | |||||||||
| Allocation: | Randomized | |||||||||
| Intervention Model: | Parallel Assignment | |||||||||
| Masking: | None (Open Label) | |||||||||
| Primary Purpose: | Treatment | |||||||||
| 5. | A Randomized Study to Evaluate the Efficacy of Herbal Ingredients Combined With a Carrier System (Phytonail) Compared With Amorolfine 5% Nail Lacquer (Loceryl) in the Treatment of Toenail Onychomycosis | Onychomycosis | Drug: Phytonail Other Name: herbal ingredients combined with a carrier system (Phytonail) Drug: Loceryl Other Name: amorolfine 5% nail lacquer (Loceryl) |
Study Type: | Interventional (Clinical Trial) | - | Taiwan | Unknown | Mycological cure (Time Frame: At week 16) | [92] |
| Estimated Enrollment: | 72 participants | |||||||||
| Allocation: | Randomized | |||||||||
| Intervention Model: | Parallel Assignment | |||||||||
| Masking: | None (Open Label) | |||||||||
| Primary Purpose: | Treatment | |||||||||
| 6. | Omega-3, Nigella Sativa, Indian Costus, Quinine, Anise Seed, Deglycyrrhizinated Licorice, Artemisinin, Febrifugine on Immunity of Patients With (COVID-19) | Covid19 Immunodeficiency |
Drug: Omega 3/Nigella Sativa Oil Drug: Omega 3/Nigella Sativa Oil/Indian Costus Drug: Omega 3/Nigella Sativa Oil/Quinine pills Drug: Omega 3/Nigella Sativa Oil/Anise seed capsule Drug: Omega 3/Nigella Sativa Oil/Deglycyrrhizinated Licorice Drug: Active Comparator |
Study Type: | Interventional (Clinical Trial) | II and III | Saudi Arabia | Recruiting | Clinical improvement (Time Frame: 30 Days) Time to Clinical recovery Recovery rate from positive to negative swaps (Time Frame: 14 Days) |
[93] |
| Estimated Enrollment: | 200 participants | |||||||||
| Allocation: | Randomized | |||||||||
| Intervention Model: | Sequential Assignment | |||||||||
| Masking: | Double (Participant, Care Provider) | |||||||||
| Primary Purpose: | Treatment | |||||||||
| 7. | Use of Vagitories based on St. John’s Wort, Tea Tree Oil and Shepherd’s Purse in the Treatment of Vaginal Inflammation | Non-Specific Vaginitis | Drug: Shepherd’s Purse extractum oleosum vagitories Drug: Tea tree vagitories Drug: Hyperici extractum oleosum vagitories Drug: Vagitories—Probiotic |
Study Type: | Interventional (Clinical Trial) | IV | Bosnia and Herzegovina | Complete | Change in objective symptoms of non-specific vaginitis, assessed by gynecological examination (Time Frame: 1 day after treatment completion) | [94] |
| Actual Enrollment: | 210 participants | |||||||||
| Allocation: | Randomized | |||||||||
| Intervention Model: | Parallel Assignment | |||||||||
| Masking: | None (Open Label) | |||||||||
| Primary Purpose: | Treatment | |||||||||
| 8. | Efficacy of a Plaque Disclosing Toothpaste on Home Oral Hygiene Procedures | Chronic Gingivitis, Plaque Induced | Other: Colgate toothpaste fluoridated Other: Shoplaq toothpaste Active Ingredient -Sodium Monofluorophosphate 1000 PPM Ingredients -Precipitated Calcium Carbonate, Sorbitol, Glycerin, Precipitated Silica, Sodium Carboxy Methyl Cellulose, Sodium Benzoate, DM Water, Colour CI-45410, Holy Basil Oil, Neem Oil, Citrus Oil, Thymol Oi, Clove Oil, Piper Betel Leaf Oil, Tea Tree Oil, Eucalyptus Oil, Peppermint Oil, Spearmint Oil. Dye containing tooth paste for disclosing plaque and efficient brushing for better oral health. |
Study Type: | Interventional (Clinical Trial) | - | Malaysia | Unknown | Plaque removal efficacy of a disclosing toothpaste (Time Frame: from Baseline to 1 year) | [95] |
| Estimated Enrollment: | 50 participants | |||||||||
| Allocation: | Randomized | |||||||||
| Intervention Model: | Parallel Assignment | |||||||||
| Intervention Model Description: | interventional preventive trial | |||||||||
| Masking: | Double (Care Provider, Outcomes Assessor) | |||||||||
| Masking Description: | Toothpaste tubes will be masked so the care provider would not know which tube he/she allocating to the participants as well the outcome assessor would be masked from both groups (test and control) so data is assessed unbiased. | |||||||||
| Primary Purpose: | Prevention | |||||||||