Table 2.
Effect of CoQ10on antioxidants and oxidative stress markers in the hippocampus of rats subjected to PTZ kindling.
| Rats Groups N = 6 |
Antioxidants and Oxidative Stress Markers | |||
|---|---|---|---|---|
| GSH ng/mg |
ROS Unit/mg |
MDA nmol/mg |
PC nmol/mg |
|
| Control | 101.18 ± 22.07 | 1077.18 ± 41.16 | 1.97 ± 0.41 | 1.216 ± 0.1 |
| PTZ | 19.5 ± 4.7 S * | 1271.2 ± 48.07 * | 7.64 ± 0.6 * | 1.945 ± 0.12 * |
| PTZ/VPA | 85.34 ± 6.5 #, | 1236.6 ± 41.53 | 6.70 ± 0.7 # | 1.737 ± 0.09 # |
| PTZ/COQ10 | 95.88 ± 2.45 # ↑80% |
1127.5 ± 41 ↓11% |
3.52 ± 0.66 # ↓50% |
1.422 ± 0.16 # |
| PTZ/VPA + COQ10 | 113.38 ± 3.5 #,$ ↑25% |
1062.64 ± 40.13 S #,$ ↓14% |
3.37 ± 0.46 #,$ ↓54% |
1.412 ± 0.13 # |
Data are expressed as the mean ± the standard error of the mean, one-way ANOVA, and post hoc Tukey’s test. COQ10: Coenzyme Q10; GSH: reduced Glutathione; MDA: Malondialdehyde; PC: Protein Carbonyl; PTZ: Pentylenetetrazole; ROS: reactive oxygen species; VPA: Valproic acid. * p < 0.05 compared to the control; # p < 0.05, compared to the PTZ group alone; $ p < 0.05 for the PTZ/VPA + COQ10 group compared to the PTZ/VPA group. Percentages were calculated in comparison to the PTZ group ↑ = Increase, ↓ = Decrease. n = number.