Table 3.
Effect of CoQ10 on antioxidants and oxidative stress markers in the hepatic tissue of rats subjected to PTZ kindling.
| Rats Groups N = 6 |
Antioxidants and Oxidative Stress Markers | ||||
|---|---|---|---|---|---|
| GSH ng/mg |
ROS Unit/mg |
MDA nmol/mg |
PC nmol/mg |
CYP2EL ng/mg |
|
| Control | 135.42 ± 4.08 | 1077.20 ± 50.4 | 2.35 ± 0.4 | 1.564 ± 0.09 | 18 ± 2.053 |
| PTZ | 30.56 ± 4.41 * | 1395.5 ± 58.7 * | 9.74 ± 0. 3 * | 2.230 ± 0.09 * | 96.42 ± 4.71 * |
| PTZ/VPA | 95.12 ± 5.23 # | 1204 ± 32.4 | 9.34 ± 0.35 | 1.95 ± 0.06 | 73.44 ± 5.78 # |
| PTZ/COQ10 | 130.3 ± 6.5 # ↑76% |
1116.9 ± 12.6 # ↓20% |
3.17 ± 0.7 # ↓67% |
1.852 ± 0.08 # ↓17% |
61.1 ± 1.055 # ↓36% |
| PTZ/VPA + COQ10 | 133.7 ± 3.3 #,$ ↑29% |
998.1 ± 32 #,$ ↓25% |
5.22 ± 0.61 #,$ ↓44% |
1.82 ± 0.04 # | 67.04 ± 4.097 # |
Data are expressed as the mean ± the standard error of the mean, one-way ANOVA, and post hoc Tukey’s test. COQ10: Coenzyme Q10; GSH: reduced Glutathione; MDA: Malondialdehyde; PC: Protein Carbonyl; PTZ: Pentylenetetrazole; ROS: reactive oxygen species; VPA: Valproic acid.* p < 0.05 compared to the control; # p < 0.05, compared to the PTZ group alone; $ p < 0.05 for the PTZ/VPA + COQ10 group compared to the PTZ/VPA group. The percentages were calculated in comparison to the PTZ group. ↑ = Increase, ↓ = Decrease. n = number.