Table 1.

Antibiotic index relative rate and antibiotic prescription relative rate by class with 95% CI adjusted for calendar year, patients’ age, sex, and geographical location (Pedianet 2012–2018).

	Relative Risk
	AI	Amoxicillin	Co-Amoxiclav	III-Gen. Cephalosporins	II-Gen. Cephalosporins	Macrolides	Lincosamides	Fluoroquinolones	J01XX	Thiamphenicol	Other Aminoglycosides	Other
Time in year	0.96 (0.96–0.97)	1.02 (1.01–1.02)	1.01 (1.01–1.02)	1 (1–1)	0.9 (0.89–0.9)	0.99 (0.99–0.99)	1.03 (0.99–1.07)	0.91 (0.85–0.96)	0.98 (0.96–1)	1.02 (1.01–1.03)	0.95 (0.94–0.96)	0.83 (0.8–0.86)
Patients’ age in years	0.87 (0.87–0.87)	0.94 (0.94–0.94)	1.01 (1.01–1.01)	1.01 (1.01–1.01)	0.93 (0.93–0.94)	1.04 (1.04–1.04)	1.2 (1.18–1.23)	1.13 (1.09–1.17)	1.17 (1.16–1.18)	0.94 (0.93–0.94)	1.14 (1.13–1.15)	1.07 (1.05–1.09)
Male sex	1.05 (1.04–1.06)	0.99 (0.97–1)	1.04 (1.03–1.05)	0.97 (0.96–0.99)	0.91 (0.89–0.94)	1.03 (1.02–1.04)	1.32 (1.13–1.54)	1.38 (1.08–1.76)	1.02 (0.94–1.1)	0.55 (0.52–0.57)	1 (0.94–1.05)	1.11 (0.97–1.26)
Geographical location
North	ref	ref	ref	ref	ref	ref	ref	ref	ref	ref	ref	ref
Centre	1.72 (1.71–1.74)	0.35 (0.35–0.36)	1.8 (1.78–1.83)	1.37 (1.35–1.4)	1.59 (1.53–1.65)	0.92 (0.9–0.94)	0.38 (0.28–0.5)	4.4 (3.01–6.41)	0.51 (0.46–0.56)	1.5 (1.4–1.61)	0.71 (0.66–0.77)	0.84 (0.72–0.99)
South and islands	1.75 (1.74–1.76)	0.28 (0.28–0.29)	1.33 (1.31–1.34)	1.96 (1.93–1.99)	1.88 (1.83–1.94)	1.33 (1.32–1.35)	0.88 (0.75–1.03)	3.22 (2.27–4.57)	0.27 (0.25–0.3)	1.98 (1.87–2.09)	0.81 (0.76–0.86)	0.23 (0.19–0.28)