Table 2.
Heat map of antibiotic treatment switching rate (overall, early, and late) stratified by diagnosis with the mean and the median day of switching. Only treatment switches with a prevalence rate by diagnosis higher than 5% are reported (Pedianet, 2012–2018).
| Diagnosis | Treatment Switch | N of Total Switches (% of Overall Switches) | N of Total Switches (% of Overall Switches by Diagnosis) | N of Early Switches (% of Overall Early Switches by Diagnosis) | N of Late Switches (% of Overall Late Switches by Diagnosis) | Mean (SD) | Median (IQR) |
|---|---|---|---|---|---|---|---|
| AOM | Amoxicillin–co-amoxiclav | 220 (1.3) | 220 (9.6) | 20 (5.1) | 200 (10.2) | 9.4 (3.7) | 10 (6) |
| Amoxicillin–III-gen. cephalosporins | 215 (1.3) | 215 (9.4) | 35 (8.9) | 180 (9.2) | 8.8 (4.3) | 10 (8) | |
| Amoxicillin–macrolides | 144 (0.8) | 144 (6.3) | 22 (5.6) | 122 (6.2) | 8.7 (4.1) | 9.5 (6.2) | |
| Co-amoxiclav–III-gen. cephalosporins | 382 (2.2) | 382 (16.7) | 68 (17.3) | 314 (16) | 8.5 (4.2) | 9 (7) | |
| Co-amoxiclav–macrolides | 186 (1.1) | 186 (8.1) | 22 (5.6) | 164 (8.3) | 9.2 (4.1) | 10 (7) | |
| III-gen. cephalosporins–co-amoxiclav | 215 (1.3) | 215 (9.4) | 36 (9.2) | 179 (9.1) | 8.4 (4.1) | 9 (7) | |
| III-gen. cephalosporins–Macrolides | 150 (0.9) | 150 (6.6) | 17 (4.3) | 133 (6.8) | 8.7 (3.8) | 9 (5.5) | |
| Bronchitis/bronchiolitis | Amoxicillin–macrolides | 299 (1.7) | 299 (11.2) | 44 (8.2) | 255 (11.7) | 7.6 (3.7) | 7 (5.5) |
| Co-amoxiclav–macrolides | 480 (2.8) | 480 (18) | 80 (14.9) | 400 (18.3) | 7.6 (3.8) | 7 (7) | |
| III-gen. cephalosporins–macrolides | 247 (1.4) | 247 (9.3) | 37 (6.9) | 210 (9.6) | 7.9 (3.8) | 8 (6) | |
| Macrolides–amoxicillin | 148 (0.9) | 148 (5.6) | 39 (7.3) | 109 (5) | 7 (4.2) | 6 (8) | |
| Macrolides–co-amoxiclav | 427 (2.5) | 427 (16) | 87 (16.2) | 340 (15.5) | 6.9 (3.9) | 7 (6) | |
| Macrolides–III-gen. cephalosporins | 409 (2.4) | 409 (15.3) | 86 (16) | 323 (14.8) | 7.1 (3.9) | 7 (6) | |
| Pharyngitis | Amoxicillin–co-amoxiclav | 285 (1.7) | 285 (8.8) | 33 (4.6) | 252 (9.6) | 9.4 (4) | 10 (6) |
| Amoxicillin–III-gen. cephalosporins | 248 (1.4) | 248 (7.6) | 50 (6.9) | 198 (7.6) | 8.8 (4.5) | 10 (9) | |
| Amoxicillin–macrolides | 275 (1.6) | 275 (8.5) | 48 (6.6) | 227 (8.7) | 8.4 (4.2) | 9 (8) | |
| Co-amoxiclav–III-gen. cephalosporins | 411 (2.4) | 411 (12.7) | 123 (17) | 288 (11) | 7 (4.6) | 7 (8) | |
| Co-amoxiclav–macrolides | 406 (2.4) | 406 (12.5) | 72 (10) | 334 (12.7) | 8.3 (4.2) | 8 (7) | |
| III-gen. cephalosporins–co-amoxiclav | 249 (1.5) | 249 (7.7) | 51 (7.1) | 198 (7.6) | 8.3 (4.4) | 9 (9) | |
| III-gen. cephalosporins–macrolides | 268 (1.6) | 268 (8.3) | 28 (3.9) | 240 (9.2) | 8.7 (3.9) | 9 (7) | |
| URTI | Amoxicillin–co-amoxiclav | 230 (1.3) | 230 (5.1) | 30 (4.2) | 200 (5.1) | 8.5 (4) | 8.5 (8) |
| Amoxicillin–macrolides | 359 (2.1) | 359 (8) | 54 (7.6) | 305 (7.8) | 7.7 (3.7) | 7 (6) | |
| Co-amoxiclav–III-gen. cephalosporins | 338 (2) | 338 (7.5) | 75 (10.5) | 263 (6.7) | 7.9 (4.3) | 8 (7.8) | |
| Co-amoxiclav–macrolides | 566 (3.3) | 566 (12.6) | 85 (11.9) | 481 (12.2) | 7.9 (3.9) | 8 (6) | |
| III-gen. cephalosporins–co-amoxiclav | 234 (1.4) | 234 (5.2) | 37 (5.2) | 197 (5) | 8.7 (4) | 9 (6) | |
| III-gen. cephalosporins–macrolides | 275 (1.6) | 275 (6.1) | 30 (4.2) | 245 (6.2) | 8.4 (3.8) | 8 (6) | |
| Macrolides–co-amoxiclav | 664 (3.9) | 664 (14.8) | 87 (12.2) | 577 (14.7) | 8 (3.8) | 7 (7) | |
| Macrolides–III-gen. cephalosporins | 470 (2.7) | 470 (10.4) | 79 (11.1) | 391 (10) | 7.7 (4) | 7 (7) | |
| NA | Amoxicillin–co-amoxiclav | 139 (0.8) | 139 (5.4) | 25 (4.8) | 114 (5.4) | 8.3 (4.2) | 8 (7.5) |
| Amoxicillin–macrolides | 144 (0.8) | 144 (5.6) | 24 (4.6) | 120 (5.7) | 7.5 (3.8) | 7 (7) | |
| Co-amoxiclav–III-gen. cephalosporins | 261 (1.5) | 261 (10.2) | 55 (10.6) | 206 (9.8) | 7.8 (4.1) | 8 (8) | |
| Co-amoxiclav–macrolides | 418 (2.4) | 418 (16.3) | 75 (14.4) | 343 (16.3) | 7.9 (4.1) | 7 (8) | |
| III-gen. cephalosporins–co-amoxiclav | 189 (1.1) | 189 (7.4) | 39 (7.5) | 150 (7.1) | 8 (4.4) | 8 (9) | |
| III-gen. cephalosporins–macrolides | 163 (1) | 163 (6.4) | 24 (4.6) | 139 (6.6) | 7.8 (3.8) | 7 (6.5) | |
| Macrolides–co-amoxiclav | 244 (1.4) | 244 (9.5) | 45 (8.6) | 199 (9.5) | 7.7 (4.1) | 7 (8) | |
| Macrolides–III-gen. cephalosporins | 130 (0.8) | 130 (5.1) | 31 (6) | 99 (4.7) | 7.1 (4) | 7 (7) |