PH	pulmonary hypertension
PA	pulmonary artery
PAH	pulmonary arterial hypertension
PVR	pulmonary vascular resistance
RV	right ventricular
RHF	right-heart failure
RVH	right-ventricular hypertrophy
mPAP	mean pulmonary artery pressure
LVEDP	left-ventricular end-diastolic pressure
WU	Wood units
WHO	World Health Organization
COPD	chronic obstructive pulmonary disease
IPAH	idiopathic PAH
HPAH	heritable PAH
APAH	associated PAH
PASMCs	pulmonary arterial smooth muscle cells
PAECs	pulmonary arterial endothelial cells
PAADCs	pulmonary arterial adventitial cells
HDMs	histone demethylases
HDACs	histone deacetylases
Sirt1	Sirtuin-1
Sirt3	Sirtuin-3
Sirt4	Sirtuin-4
BRD4	bromodomain-containing protein 4
5-HT	5-hydroxytryptamine
ERAs	endothelin receptor antagonists
PCAs	prostacyclin analogues
PDE-Is	phosphodiesterase 5 inhibitors
sGCs	soluble guanylate cyclase stimulators
FDA	the US Food and Drug Administration
CCBs	calcium channel blockers
NO	nitric oxide
cGMP	cyclic guanosine monophosphate
sGC	soluble guanylyl cyclase
PDE5	phosphodiesterase-5
cGMP	cyclic guanosine monophosphate
GMP	guanosine monophosphate
PGI2	prostacyclin
cAMP	cyclic adenosine monophosphate
PKA	protein kinase A,
SC	subcutaneous
IV	infusion
ECE	endothelin-converting enzyme
IP3	inositol triphosphate
E2	estradiol
DHEA-S	dehydroepiandrosterone sulfate
Treg	regulatory T cells
Erα	estrogen receptor alpha
Erβ	estrogen receptor beta
TFAM	mitochondrial transcription factors
NFAT	nuclear factor of activated T-cells
NLPR3FSP-1	NLR (NOD like receptor) family pyrin domain-containing 3 fibroblast-specific protein 1
CD31	platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31
CYP1B1	cytochrome P450 family 1 subfamily B member 1
ncRNAs	noncoding RNAs
lncRNAs	long noncoding RNAs
circRNAs	circular RNAs
CpG	cytosine-phosphate-guanine
DNMTs	DNA methyltransferases
MTase	methyltransferase
H3K3me3	histone 3 lysine 4 trimethylation
H3K27me3	histone 3 lysine 27 trimethylation
K4me3	lysine 4 trimethylation
MeCP1	methylated CpG-binding protein 1
MeCP2	Methylated CpG-binding protein 2
MBDs	methyl-CpG-binding domain proteins
SOD2	superoxide dismutase 2
FHR	Fawn-hooded rats
HIF-1α	hypoxia-inducible factor
Kv1.5	voltage-gated K+ channels
siRNA	small interfering RNA
BMPR2	bone morphogenetic protein receptor 2
TBX4	T-box 4
ACVRL1	activin A receptor-like type 1
ENG	endoglin
SMAD9	small mothers against decapentaplegic homolog 9
CAV1	caveolin-1
KCNK3	potassium channel subfamily K member 3
ATP13A3	ATPase 13A3
SOX17	SRY-box 17
AQP1	aquaporin 1
BMP9 (GDF2)	growth differentiation factor 2
EIF2AK4	eukaryotic translation initiation factor 2 alpha kinase 4
TGF-β	transforming growth factor beta
BMP/TGF	bone morphogenic protein/transforming growth factor
WES	whole genome sequencing
SPS	small-patella syndrome
HMTs	histone methyltransferases
JmjC	Jumonji C family
LSD	lysine-specific demethylases
FAD	flavin adenine dinucleotide
α-KG	α-ketoglutarate
CAM	cell adhesion molecules
ICAMs	intercellular adhesion molecules
VCAMs	vascular cell adhesion molecules
MRTF-A	myocardin-related transcription factor A
NF-κB	nuclear factor kappa B
ASH2	small homeotic 2
WDR5	WD repeat domain 5
EZH2	enhancer of zeste homolog 2
TAC	transverse aortic constriction
ROS	reactive oxygen species
SOD1	superoxide dismutase type 1
GSK-J4	a KDM6B inhibitor
LSD1	lysine-specific histone demethylase 1A
HATs	histone acetyltransferases
HDACs	histone deacetylases
BRDPs	bromodomain-containing proteins
eNOS	endothelial nitric oxide synthase
PPHN	persistent PH of the newborn
PAB	pulmonary artery banding
MCT	monocrotaline
TSA	trichostatin A
VPA	valproic acid
MEF2	myocyte enhancer factor 2
IGF-1/pAKT	insulin-like growth factor-1/phosphorylation of protein kinase B
RVSP	RV systolic pressure
CO	cardiac output
TPR	pulmonary vascular resistance
BRD	bromodomain
BET	bromodomain and extra-terminal domain
BCL2	B-cell lymphoma 2
FOXM1	Forkhead Box M1
NAD+	nicotinamide adenine dinucleotide
FOXO1	Forkhead box protein O1
CR	calorie restriction
MnSOD	manganese superoxide dismutase
SOD2	superoxide dismutase 2
Cat	catalase
Sirt3KO	Sirtuin-3 knockout
PDK	pyruvate dehydrogenase kinase
PDH	pyruvate dehydrogenase complex
GDH	glutamate dehydrogenase
DCA	dichloroacetate
UCP2	uncoupling protein 2
PI3K/AKT	phosphoinositide 3-kinase/protein kinase B
Sphk1	sphingosine kinase 1
SP1	specificity protein 1
Pri-miRNAs	primary miRNAs
RISC	RNA-induced silencing complex