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. 2021 Dec 24;11(1):41. doi: 10.3390/antiox11010041

Figure 4.

Figure 4

Study of the mitochondrial oxygen consumption rate (OCR) in SN4741 neuronal cells after 90 min of incubation with the combination of corticosterone and MPP+ (CORT + MPP+) in the presence or absence of IGF-II. (a) Representative experiment of the measurement of key parameters using the Mito Stress test kit. Blue line: control; green line: presence of IGF-II; red line: combination of the two drugs (CORT + MPP+); (b) basal consumption after 90 min of incubation; (c) ATP production; (d) proton leak; (e) spare respiratory capacity; (f) maximal respiration. Data from six to eight independent experiments were combined and presented as mean ± SEM. * p < 0.05 compared to control cells; & p < 0.05 compared to CORT + MPP+ co-incubated cells.