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The target protein is ubiquitinated and transported to the 26S proteasome for degradation. Proteasome inhibitors bind to the β subunit of the catalytic core, thereby inhibiting the degradation of antitumor-related protein products. E1: ubiquitin-activating enzyme; E2: ubiquitin-binding enzyme; E3: ubiquitin-linker enzyme; Ub: ubiquitin.
