Table 3.

Bias-adjusted results from the parsimonious Cox models with significant CD163 metrics.

Model with Number of CD${163}^{+}$ TAMs	Hazard Ratio (*)	LL 95% CI	UL 95% CI	p-Value
Histological Grade 2 vs. 1	2.01	0.92	4.39	0.086
Histological Grade 3 vs. 1	2.42	1.05	5.58	0.042
HR- vs. HR+ Hormone Tx compliant	1.52	0.78	3.00	0.226
HR+ Hormone Tx Non-Compliant vs. Compliant	2.74	1.43	5.24	0.004
Node Positive vs. Negative	1.84	1.10	3.07	0.022
Tumor Size 2–5 cm vs. <2 cm	1.96	1.15	3.36	0.016
Tumor Size >5 cm vs. <2 cm	2.93	1.53	5.61	0.002
High vs. Low Number of CD${163}^{+}$ TAMs	1.89	1.05	3.41	0.039
Model with Median Cancer-to-CD${\mathbf{163}}^{+}$ NND	Hazard Ratio (*)	LL 95% CI	UL 95% CI	p -Value
Histological Grade 2 vs. 1	2.35	1.08	5.11	0.036
Histological Grade 3 vs. 1	2.87	1.26	6.53	0.015
HR- vs. HR+ Hormone Tx Compliant	1.90	1.00	3.61	0.055
HR+ Hormone Tx Non-Compliant vs. Compliant	2.71	1.39	5.28	0.005
Node Positive vs. Negative	1.78	1.06	2.97	0.032
Tumor Size 2–5 cm vs. <2 cm	1.85	1.08	3.17	0.029
Tumor Size >5 cm vs. <2 cm	2.76	1.44	5.30	0.003
Low vs. High Median Cancer-to-CD${163}^{+}$ NND	1.88	1.03	3.44	0.024
Model with Average Number of Adjacent $\mathbf{CD}{\mathbf{163}}^{+}$ TAMs	Hazard Ratio (*)	LL 95% CI	UL 95% CI	p -Value
Histological Grade 2 vs. 1	1.99	0.91	4.36	0.090
Histological Grade 3 vs. 1	2.18	0.94	5.04	0.074
HR- vs. HR+ Hormone Tx Compliant	1.71	0.89	3.29	0.111
HR+ Hormone Tx Non-Compliant vs. Compliant	2.61	1.37	4.97	0.005
Node Positive vs. Negative	1.84	1.11	3.07	0.022
Tumor Size 2–5 cm vs. <2 cm	1.97	1.15	3.36	0.016
Tumor Size >5 cm vs. <2 cm	2.76	1.44	5.28	0.003
High vs. Low Average Number of adjacent CD${163}^{+}$ TAMs	1.78	1.09	2.89	0.024
Model with Average Number of Communicating $\mathbf{CD}{\mathbf{163}}^{+}$ TAMs	Hazard Ratio (*)	LL 95% CI	UL 95% CI	p -Value
Histological Grade 2 vs. 1	2.25	1.03	4.92	0.045
Histological Grade 3 vs. 1	2.85	1.24	6.57	0.016
HR- vs. HR+ Hormone Tx Compliant	1.48	0.75	2.91	0.267
HR+ Hormone Tx Non-Compliant vs. Compliant	2.55	1.32	4.92	0.008
Node Positive vs. Negative	1.79	1.08	2.97	0.027
Tumor Size 2–5 cm vs. <2 cm	1.81	1.06	3.09	0.034
Tumor Size >5 cm vs. <2 cm	2.77	1.45	5.28	0.003
High vs. Low Average Number of communicating CD${163}^{+}$ TAMs	2.33	1.37	3.98	0.003

(*) Bootstrap-based optimistic bias-adjusted hazard ratio.