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TGFβ latent complex, activation, and signaling. TGFβ is produced in the small latent complex that binds intracellularly with a latent TGFβ-binding protein to form the large latent complex, which associates extracellularly with fibrillin-1 microfibrils. After integrin/protease-mediated activation and release, TGFβ signals through receptor-mediated activation of the canonical Smad2/3 pathway.
