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Effect of SERPINE1 on glioblastoma cell invasion. Transcriptome profiling of motile and nonmotile glioblastoma cells identified SERPINE1 as a regulator of glioblastoma cell motility. Inhibition or knock-down of SERPINE1 reduces glioblastoma cell invasion by regulating cell adhesion and directional persistence of the cells. As a result, SERPINE1 inhibition has the potential to reduce tumor progression in vivo. Figure generated at Biorender.com (adapted from Seker, F., et al. [149]).
