Table 1.

Molecules identified as having a role in glioblastoma invasion by unbiased, high-throughput approaches.

Approach	Gene/Protein Identified	Reference
Differential expression analysis of tumor cells from tumor core and the invasive rim by laser-capture microdissection	P311	[144]
Microarray analysis of the cells from tumor cores and the cells that invaded White matter using laser-capture microdissection	ATX and BCLW	[145]
Microarray analysis of core and rim cells using cell-line spheroids invading collagen	MKK3 and p38	[146]
Microarray analysis of cell lines and primary cultures with radial migration assay	CTGF	[147]
RNA sequencing of motile and nonmotile cells using a spheroid dispersal model	SERPINE1	[149]
Differential expression analysis of long noncoding RNAs in glioma tissues, compared to normal brain tissues	NEAT1	[150]
miRNA profiling of slow-growing, diffusely infiltrating glioma and noninvasive primitive neural tumors	miRNA-449a	[151]
Functional screen with monoclonal antibody library generated against primary glioblastoma cells	Itga7	[152]
Analysis of enriched proteins on the cell membranes with different invasive capacities	Itga5, CD97 and Anxa1	[153]
Analysis of proteins in cell lines with different invasive capacities	Cathepsin D	[154]
Functional proteomics approach with fluorophore-assisted light inactivation	Neuropilin-1 and Semaphorin3A	[155]
Functional proteomics approach with fluorophore-assisted light inactivation	CD155/PVR	[156]
Analysis of proteins from glioblastoma sections by microdissecting cells from invasive border and proliferative core	ELMO1 and Dock180	[157]
Proteomics analysis of xenograft models generated by serial transplantation of human glioblastoma specimens into rat brains	PDI	[158]