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Mechanism of action of anti PD-1/L1. Activated T cells express PD-1, and when it binds to PD-L1/2 on tumor cells, it results in T-cell depletion. Durvalumab, avelumab and atezolizumab block PD-L1, while pembrolizumab and nivolumab block PD-1 to produce antitumor responses.
