Table 3.
Protein expressions’ change of mtOXPHOS and other relevant proteins in tumors compared to normal tissues.
| Identified Proteins | Gene Name | Fold Change | p-Value |
|---|---|---|---|
| mt-OXPHOS | |||
| NADH-ubiquinone oxidoreductase chain 4 | ND4 | 1.8 | 0.3 |
| NADH-ubiquinone oxidoreductase chain 5 | ND5 | 1.6 | 0.71 |
| Cytochrome c oxidase subunit 2 | COX2 | 0.9 | 0.61 |
| ATP synthase subunit | ATP6 | 1.2 | 0.52 |
| ATP synthase protein 8 | ATP8 | * | 0.12 |
| Other Mitochondrial Proteins | |||
| Dynamin-1-like protein | DNM1L | 7.4 | 0.011 |
| Protein-L-isoaspartate O-methyltransferase | PCMT1 | 5.9 | 0.0029 |
| Voltage-dependent anion-selective channel protein 3 | VDAC3 | 2.6 | 0.045 |
| ATP synthase subunit gamma | ATP5F1C | 1.9 | 0.028 |
| ATP synthase subunit d, mitochondrial | ATP5H | 1.9 | 0.019 |
| ATP synthase subunit gamma | ATP5F1C | 1.9 | 0.028 |
| ATP synthase subunit d, mitochondrial | ATP5H | 1.9 | 0.019 |
| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13 | NDUFA13 | 1.8 | 0.045 |
| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5 | NDUFA5 | 1.3 | 0.028 |
| Cytochrome c oxidase subunit 7C | COX7C | 0.7 | 0.023 |
| Cytochrome b-c1 complex subunit 6 | UQCRH | 0.6 | 0.0033 |
| Trifunctional enzyme subunit alpha | HADHA | 0.6 | 0.0066 |
| Isocitrate dehydrogenase (NAD) subunit alpha | IDH3A | 0.4 | 0.00086 |
| Phosphoglycerate kinase 1 | PGK1 | 0.4 | 0.004 |
| Electron transfer flavoprotein–ubiquinone oxidoreductase | ETFDH | 0.3 | 0.0028 |
| Glutathione S-transferase | GSTM3 | 0.2 | 0.045 |
| Pyruvate carboxylase | PC | 0.1 | 0.024 |
| Succinate-CoA ligase (GDP-forming) subunit beta | SUCLG2 | 0.06 | 0.00049 |
| Acetyl-CoA acetyltransferase | ACAT1 | 0.02 | 0.00023 |
| NADPH: adrenodoxin oxidoreductase, | FDXR | 0.004 | <0.00010 |
* Detected only in tumors.