Figure 2.

Associations between lysine acetylation and cancer hallmarks. Lysine acetylation dynamically interacts with cancer cell metabolism as acetyl-CoA is the acetyl-donor of acetylation, and acetylation could modulate cell metabolism if occurring on proteins affecting the expression of TFs or enzymes involved in cellular metabolism. Lysine acetylation, if residing in genes regulating core elements of adaptive or innate immune response, could lead to aberrant immune and inflammatory responses. Lysine acetylation is involved in genome integrity control as it could orchestrate the DDR machinery activities via modulating chromatin structure where many DDR events occur and could thus affect replication fidelity. Lysine acetylation could modulate cancer cell live/death and metastasis as it can occur on histone or non-histone proteins relevant to DDR, cell cycle progression and metastasis.