Table 2.
Nrf2-related therapeutic effects of curcumin in ischemia-reperfusion (IR) injury.
| Type of Disease | Type of Curcumin | Animals | Dose Range | Cell Line | Dose Range | Targets and Other Pathways |
Function | Ref. |
|---|---|---|---|---|---|---|---|---|
| I/R-Induced Cardiac Damage | CUR analog 14p | Male C57BL/6 mice | Cur: 100 mg/kg/day, 14p: 10 mg/kg/day, given orally to the mice for consecutive 7 days before myocardial ischemia |
H9c2 | 10 μM | Bax, Bcl-2, Caspase-3 | CUR analog 14p via activating Nrf2 and decreasing oxidative stress could protect against myocardial I/R injury. | [27] |
| Hepatic I/R Injury | CUR | Male Albino rats | 400 mg/kg, orally, daily, 14 days | - | - | HO-1, TNF-α, IL-1β, Il-6, iNOS |
CUR via Nrf2/HO-1 activation could attenuate hepatic I/R injury. | [28] |
| Cerebral I/R Injury | CUR | Male Wistar rat | 300 mg/kg, I.P., 30 min after occlusion | - | - | NF-κB | CUR via elevating Nrf2 and down-regulating NF-κB could reduce neurological dysfunction and brain edema after cerebral I/R. | [29] |