Figure 3.

The adult hippocampal neurogenic process is hallmarked by the development and subsequent maturation of stem cells into granular cell layer neurons (GCL) in the dentate gyrus (DG). Initiation of this functional journey begins with radial-glia-like stem cells in the hippocampal subgranular zone (SGZ) which differentiate into multipotent progenitors (Type ii a and b) and then into immature neuroblasts/neurons that are subsequentially fated to mature granular cell layer neurons taking approximately four weeks beginning from radial glia-like stem cells and ending with mature GCL neurons. A subset of neurogenesis related immunohistochemical markers that can be utilized to distinguish stages and cell types of adult neurogenesis.