Table 1.

Model parameters and parameter search ranges for PSMSR, including the 95% confidence limits.

Condition	K	Kb	KGs 0	KGt 0	Kstr	Kstr,d	a	b	g	Sdrug	AUCs 5	AUCs 95	SCALEs	AUCt 5	AUCt 95	SCALEt
Heterotypic	0.049 ± 0.0003	3.57 ± 0.02	0.713 ± 0.001	0.687 ± 0.004	7.14 × 10−4 ± 3 × 10−6	5.64 × 10−3 ± 4 × 10−5	0.046 ± 0.0004	0.038 ± 0.0002	0.018 ± 0.0006
Heterotypic, 3 weeks	0.052 ± 0.0007	2.6 ± 0.05	0.708 ± 0.002	0.189 ± 0.016	6.74 × 10−4 ± 8 × 10−6	5.52 × 10−3 ± 1 × 10−4	0.05 ± 0.001	0.038 ± 0.0006	0.02 ± 0.0006
Heterotypic, cisplatin 5 μM	0.033 ± 0.0017	0	1.033 ± 0.046	0.976 ± 0.054	5.9 × 10−4 ± 2.8 × 10−5	0	NA	0.04 ± 0.003	0.034 ± 0.003	108 ± 14.5	239 ± 12	1153 ± 58	8.61 ± 0.5	233 ± 17	1201 ± 49	5.79 ± 0.6
Heterotypic, 3 weeks, cisplatin 5 μM	0.033 ± 0.0015	0	0.966 ± 0.05	0.967 ± 0.05	5.8 × 10−4 ± 3.3 × 10−5	0	NA	0.039 ± 0.002	0.036 ± 0.003	96.8 ± 9.95	271 ± 14	1098 ± 44	8.91 ± 0.5	250 ± 14	1098 ± 47	6.89 ± 0.7
Parameter search range	0–0.1	0–5	0–2	0–2	0–0.001	0–0.02	0–0.1	0–0.1	0–0.1	1–500	1–500	10–1500	0.1–20	1–500	10–1500	0.1–20