Figure 2.

Resume of the metabolic changes taking place in tumor cells and interstitial cell subpopulations. Lactate is released into the interstitium, contributing to its acidification. The acidity and hypoxia of the interstitium and the relative deficit of glucose and amino acids induce functional changes in the various cell subpopulations of the interstitium, including myofibroblasts, endothelial cells, T lymphocytes, and macrophages, among others. All these changes mainly promote tumor growth. Upward pointing arrows indicate increased levels or activity of that molecule or pathway. The downward pointing arrows indicate the opposite. Created using BioRender.