Figure 4.

Representative micrographs of a clear cell renal cell carcinoma with high and low expression of MCT1. (a) The left panels show a hematoxylin and eosin stain, and the right panels the corresponding immunohistochemical stain for MCT1 on an adjacent tissue slice. (b) Correlation between MCT1 IHC expression and k_PL in the patient dataset imaged as part of this study (MISSION, dots represent ccRCC, the triangle the liposarcomas) (c) Box plot comparing z-transformed MCT1 expression as a function of histological tumor grade from a Cancer Genome Atlas dataset (TCGA-KIRC, yellow). (d) Kaplan–Meier plots for the association of MCT1 expression with overall and (e) progression/recurrence-free survival using an expression cut-off at the 85th percentile in the TCGA-IRC dataset. MCT1 expression was significantly associated with overall and progression/recurrence-free survival.