Table 1.
Extended criteria by tumor morphology (diameter and number of HCC).
| Criteria | Author | Year | Donor Setting | Institution | Criteria | Cases | Outcome | External Validation |
|---|---|---|---|---|---|---|---|---|
| Milan | Mazzaferro [3] | 1996 | DD | Univ. of Milan, Italy | Single tumor < 5 cm | 48 | 4-year survival rate: 75% | ◯ |
| Up to 3 tumors with diameter < 3 cm | ||||||||
| UCSF | Yao [4,5] | 2001, 2007 | DD | Univ. of California, USA | Solitary tumor < 6.5 cm | 168 | 5-year survival rate: 75.2% | ◯ |
| < 3 nodules with the largest lesion < 4.5 cm and total tumor diameter < 8 cm | ||||||||
| Total Tumor Volume (TTV) | Toso [6] | 2008 | DD | Univ. of Alberta, Canada | TTV less than 115 cm3 | 228 | Within Milan: 5-year survival rate: 82% | ◯ |
| Within TTV: 5-year survival rate: 80% | ||||||||
| Up-to-7 | Mazzaferro [7] | 2009 | DD | International multicenter | HCCs with seven as the sum of the size of the largest tumor [in cm] and the number of tumors | 1556 | Within Milan: 5-year survival rate: 73.3 % | ◯ |
| Within Up-to-7: 5-year survival rate: 71.2% | ||||||||
| Tokyo | Sugawara [8] | 2007 | LD | Univ. of Tokyo, Japan | HCC diameter: 5 cm or less, HCC number: 5 or less | 78 | 5-year survival rate: 75% | ◯ |
| Asan | Lee [9] | 2008 | LD | Asan Medical Center, Korea | HCC diameter 5 cm or less, HCC number 6 or less | 229 | 5-year survival rate: 76% | ◯ |
DD: Deceased donor, LD; Living donor, ◯: Externally validated.