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A model showing the pathways of EBV-mediated c-Myc activation in Burkitt’s lymphoma. EBNA-2 interacts with albumin D box-binding proteins (DBPs) to activate the transcription of c-Myc. Increased production of c-Myc results in the activation of the c-Myc-targeted gene to increase cell proliferation. EBV BART miRNA inhibits MAX interactor 1 (MXI1), which is known to repress the activity of c-Myc.
