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. 2022 Jan 13;12(1):127. doi: 10.3390/biom12010127

Figure 2.

Figure 2

A model showing the role of EBV gene products in the regulation of nasopharyngeal carcinoma. EBNA-1 interacts with USP7 and indirectly reduces the stability of p53, and the unstable p53 is degraded. EBNA-3 binds with p53 to inhibit apoptosis and favors cell proliferation. In addition, BART5-3p is involved in the degradation of p53 mRNA and downregulates the expression of p53. The broken arrow represents the indirect activity of EBNA1 resulting in unstable p53. The solid arrows show the direction of the associated pathways.