Table 4.
Pharmacokinetics of VIP236 and VIP126 in female NMRI nu/nu 786-O tumor-bearing mice following administration of a single i.v. dose of VIP236 (4 mg/kg) or VIP126 (1 mg/kg). The doses of VIP236 and VIP126 deliver equimolar amounts of VIP126. Pharmacokinetic parameters were estimated from mouse concentration–time profiles (n = 2 mice/timepoint).
| PK Parameters | VIP236 | VIP126 | |
|---|---|---|---|
| Dose | (mg/kg) | 4 | 1 |
| AUCinf | (µg·h/L) | 93,400 | 301 |
| CL | (L/h/kg) | 0.0428 | 3.33 |
| Cmax | (µg/L) | 112,000 | 1510 |
| Vss | (L/kg) | 0.0688 | 1.54 |
| t1/2 | (h) | 0.807 | 1.02 |