Figure 1.

A schematic depicting the process of wound healing, including four continuous phases—homeostasis, inflammation, proliferation, and remodeling. Firstly, blood platelets are activated to form a blood clot and have a role in leukocyte recruitment. Next, neutrophils and macrophages clean the wound site from dead cells, bacteria, and other pathogens or debris. Then, fibroblasts migrate, proliferate, and activate the angiogenesis process. Finally, granulation tissue is formed, the deposition of extracellular matrix proteins occurs to reconstitute the dermal tissue, and the epidermis is regenerated. Eventually, many of the formed capillaries and fibroblasts disappear [17].