Table 1.

Clinical laboratory profiles of the participants.

Variables	RRMS	AQP4-Ab NMOSD	p	Correlation Coefficient ▲
No. of participants	81	90
No. of females (%)	57 (70.3)	71 (78.9)	0.22	−0.098
Age at onset, median (range), year	30 (14–68)	48.5 (18–72)	<0.001	0.540
Age at LP, median (range), year	33 (14–68)	52 (18–72)	<0.001	0.516
CSF
Total protein, median, mg/L (range)	326 (160–1167)	381.5 (185–2883)	0.029	0.168
Albumin, median, mg/L (range)	182 (95–711)	219 (87–1790)	0.023	0.175
IgG, median, mg/L (range)	43.4 (12.2–155)	38.05 (9.3–448)	0.319	−0.076
Serum
Albumin, median, g/L (range)	42.1 (28.8–49.1)	39.75 (33.1–51.5)	<0.001	−0.279
IgG, median, g/L (range)	10.3 (4.7–21.1)	10.7 (4.1–35.7)	0.746	0.025
C3, g/L (range) #	0.75 (0.56–1.21)	0.76 (0.55–1.22)	0.484	−0.068
C4, g/L (range) #	0.18 (0.07–0.4)	0.17 (0.08–0.49)	0.797	−0.025
Qalb, median (range)	4.22 (2.05–18.37)	5.47 (2.28–49.31)	0.005	0.215
QIgG, median (range)	4.24 (1.04–14.83)	3.67 (1.12–24.62)	0.477	−0.055
IgG index, median (range)	0.87 (0.4–2.09)	0.66 (0.37–1.46)	<0.001	−0.411
No. of positive CSF-OCB (%) *	38 (67.9)	6 (23.1)	<0.001	−0.418

Abbreviations: RRMS = relapsing–remitting multiple sclerosis; AQP4-Ab NMOSD = aquaporin-4 antibody neuromyelitis optica spectrum disorder; LP = lumbar puncture; CSF = cerebrospinal fluid; C3 = complement component 3; C4 = complement component 4; Qalb = quotient of albumin in CSF and albumin in serum; QIgG = quotient of IgG in CSF and IgG in serum; CSF-OCB = oligoclonal band in CSF. # Data from 108 patients (41 with RRMS and 67 with AQP4-Ab NMOSD) were available. * Data from 82 patients (56 with RRMS and 26 with AQP4-Ab NMOSD) were available. ^▲ Spearman’s correlation analysis: a positive value means the variable was associated with AQP4-Ab NMOSD, while a negative one indicates that the variable was correlated with RRMS.