. 2021 Dec 31;12(1):69. doi: 10.3390/brainsci12010069

Table 2.

Comparison of the IgG index and CSF-OCB for differentiating between RRMS and AQP4-Ab NMOSD based on the stratification of the onset age.

Onset Age	Methods	Results	Diagnosis		k	p	Sen	Spe	PPV	NPV	PA
Onset Age	Methods	Results	RRMS	NMOSD	k	p	Sen	Spe	PPV	NPV	PA
≤38.5 y	CSF-OCB	−	12	2	0.10	0.578	0.707	0.5	0.935	0.143	0.689
≤38.5 y		+	29	2	0.10	0.578	0.707	0.5	0.935	0.143	0.689
>38.5 y		−	6	18	0.43	0.015	0.6	0.818	0.692	0.75	0.73
>38.5 y		+	9	4	0.43	0.015	0.6	0.818	0.692	0.75	0.73
Total		−	18	20	0.40	<0.001	0.679	0.769	0.864	0.526	0.707
Total		+	38	6	0.40	<0.001	0.679	0.769	0.864	0.526	0.707
≤38.5 y	IgG index	− *	13	12	0.40	<0.001	0.783	0.667	0.887	0.48	0.756
≤38.5 y		+	47	6	0.40	<0.001	0.783	0.667	0.887	0.48	0.756
>38.5 y		−	5	58	0.49	<0.001	0.762	0.806	0.533	0.921	0.796
>38.5 y		+	16	14	0.49	<0.001	0.762	0.806	0.533	0.921	0.796
Total		−	18	70	0.56	<0.001	0.778	0.778	0.759	0.795	0.778
Total		+	63	20	0.56	<0.001	0.778	0.778	0.759	0.795	0.778

* A “−” refers to an IgG index lower than the defined threshold while a “+” indicates a value greater than the defined threshold. Abbreviations: RRMS = relapsing–remitting multiple sclerosis; NMOSD = neuromyelitis optica spectrum disorder; CSF-OCB = oligoclonal band in the cerebrospinal fluid; Sen = sensitivity; Spe = specificity; PPV = positive predictive value; NPV = negative predictive value; PA = predictive accuracy.