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. 2022 Jan 12;14(2):370. doi: 10.3390/cancers14020370

Table 1.

Main features of the four prospective international study protocols (LORIS, COMET, LORD and LORETTA).

Study LORIS [11] COMET [12] LORD [13] LORETTA [14]
Country UK USA EU JAPAN
Year of activation 2014 2017 2017 2017
Accrual target (number of patients) 932 1200 1240 340
Size of the lesion Any Any Any <2.5 cm
Type of guide for biopsy Stereotactic (vacuum assisted) Stereotactic (vacuum assisted) Stereotactic (vacuum assisted) Stereotactic and ultrasound (vacuum assisted)
Hormone receptor status Any Hr*-positive only Any Hr*-positive only
Endocrine therapy Optional Optional Not allowed Mandatory
Minimum age at diagnosis 48 40 45 40
Comedonecrosis Excluded Allowed Excluded Excluded

Hr*: Hestrogen receptor.