Table 3.
Impact of CerS1 and CerS5 gene silencing on the content of individual diacylglycerol in mouse gastrocnemius muscle of HFD-fed animals. Values are mean pmol/mg of tissue ± SD; n = 8 per group; a—p < 0.05 vs. LFD.
| 16:0/16:0 | 16:0/18:0 | 16:0/18:1 | 16:0/18:2 | 18:0/18:0 | 18:0/18:1 | 18:0/18:2 | 18:1/18:1 | 18:2/18:2 | 18:0/20:0 | |
|---|---|---|---|---|---|---|---|---|---|---|
| LFD | 13.41 ± 1.74 | 83.47 ± 10.99 | 32.18 ± 4.60 | 38.09 ± 5.47 | 2.10 ± 0.22 | 21.88 ± 2.88 | 0.96 ± 0.17 | 20.98 ± 2.14 | 24.91 ± 2.43 | 3.85 ± 0.53 |
| HFD | 16.15 ± 2.47 | 144.52 ± 16.79 a | 39.36 ± 4.67 | 66.52 ± 11.60 a | 2.92 ± 0.23 a | 22.90 ± 3.65 | 1.98 ± 0.33 a | 23.37 ± 2.21 | 34.00 ± 5.15 a | 7.23 ± 0.96 a |
| HFD(-CerS1) | 18.42 ± 2.24 a | 152.99 ± 8.93 a | 36.68 ± 5.84 | 68.10 ± 10.15 a | 2.74 ± 0.28 a | 24.04 ± 1.96 | 2.19 ± 0.29 a | 22.12 ± 4.19 | 32.27 ± 3.34 a | 6.88 ± 0.88 a |
| HFD(-CerS5) | 18.79 ± 3.12 a | 156.04 ± 12.08 a | 36.98 ± 6.09 | 68.87 ± 6.31 a | 2.81 ± 0.26 a | 23.98 ± 3.72 | 2.19 ± 0.28 a | 22.01 ± 1.81 | 31.35 ± 4.94 a | 7.12 ± 0.62 a |