Table 1.

Exosomal microRNAs as Biomarkers in the Diagnosis of Ischemic Stroke.

microRNAs	Expression in IS	Sources	Models	Outcomes	References
miR-9	upregulation	serum	Human	NIHSS score, infarct volume, serum IL-6	[59]
miR-124	upregulation	serum	Human	NIHSS score, infarct volume, serum IL-6	[59]
miR-223	upregulation	serum	Human	NIHSS score, infarct volume, 3-month mRS, stroke occurrence	[60]
miR-134	upregulation	serum	Human	NIHSS score, infarct volume, serum IL-6, hs-CRP	[62]
miR-422a	upregulation in acute phase downregulation in subacute phase	plasma	Human	different stages of IS	[63]
miR-125-2-3p	downregulation	plasma	Human	different stages of IS	[63]
miR-21-5p	upregulation in subacute phase upregulation in recovery phase	plasma	Human	different stages of IS	[64]
miR-30a-5p	upregulation in hyperacute phase downregulation in acute phase	plasma	Human	different stages of IS	[64]
miR-17-5p	upregulation	serum	Human	subtypes of stroke	[65]
miR-20b-5p	upregulation	serum	Human	subtypes of stroke	[65]
miR-27b-3p	upregulation	serum	Human	subtypes of stroke	[65]
miR-93-5p	upregulation	serum	Human	subtypes of stroke	[65]
miR-15a	downregulation	serum	Human	subgroups of stroke	[66]
miR-100	downregulation	serum	Human	subgroups of stroke	[66]
miR-339	downregulation	serum	Human	subgroups of stroke	[66]
miR-424	downregulation	serum	Human	subgroups of stroke	[66]
miR-122-5p	downregulation	plasma	Rat	different stages of IS	[67]
miR-300-3p	upregulation	plasma	Rat	different stages of IS	[67]
miR-126	downregulation	serum	Rat	different stages of IS	[61]

IS, ischemic stroke; NIHSS, National Institutes of Health Stroke Scale; hs-CRP, high-sensitivity C-reactive protein.