Figure 4.

Sub-network of 24 nodes and 72 interactions extracted by applying mathematical filters to the PTPRG-specific first neighbor (FN) PPI network of 2976 nodes (interactors) connected by 123,961 binary, non-redundant, un-directed edges. The sub-network was generated by using OR and AND Boolean operators and allowed extracting the most topologically relevant nodes, all characterized by values of betweenness, centroid, degree, and bridging centralities over the average. This sub-network possibly represents a highly relevant regulatory signaling module in PTPRG physiology.