Table 5.
Distribution of HLA zygosity in our cohort, subset by HLA class I locus in relation to development of IRAE in absolute values and percent.
| HLA Class I locus | Patients Total | IRAE | Colitis | Hepatitis | Pancreatitis | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| (N) | (%) | (N) | (%) | (N) | (%) | (N) | (%) | (N) | (%) | |
| Total | 95 | 100 | 59 | 62 | 20 | 21.05 | 14 | 14.74 | 13 | 13.68 |
| HLA Homozygosity Heterozygosity |
23 72 |
24 76 |
17 42 |
74 58 |
8 12 |
35 17 |
7 7 |
30 (p = 0.015) 10 |
3 10 |
13 14 |
| HLA-A Homozygosity Heterozygosity |
13 82 |
14 86 |
10 49 |
77 60 |
5 15 |
38 18 |
4 10 |
31 12 |
2 11 |
15 13 |
| HLA-B Homozygosity Heterozygosity |
8 87 |
8 92 |
4 55 |
50 63 |
1 19 |
13 22 |
2 12 |
25 14 |
1 12 |
13 14 |
| HLA-C Homozygosity Heterozygosity |
8 87 |
8 92 |
5 54 |
63 62 |
3 17 |
38 20 |
2 12 |
25 14 |
1 12 |
13 14 |
Results analyzed in the main text are highlighted in bold.