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. 2022 Jan 7;14(2):287. doi: 10.3390/cancers14020287

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PBA treatment decreased pluripotency factors and affected cytokine production. (A) MYC, IL-10, BMP4 and PD-L1 expression levels in all populations of three BC cell lines before and after treatment with PBA. Expression of coding genes was normalized with respect to GUSB. PD-L1 surface expression is represented as the percentage of cells expressing PD-L1 on their surface. (B) IL-10, IL-4, IL-1β, CXCL-10, TNFα, CCL-2, IL-6 and IL-8 levels in cell culture supernatant after treatment with PBA before and after co-culture with macrophages. Significance is depicted as follows: * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001.

PBA treatment decreased pluripotency factors and affected cytokine production. (A) MYC, IL-10, BMP4 and PD-L1 expression levels in all populations of three BC cell lines before and after treatment with PBA. Expression of coding genes was normalized with respect to GUSB. PD-L1 surface expression is represented as the percentage of cells expressing PD-L1 on their surface. (B) IL-10, IL-4, IL-1β, CXCL-10, TNFα, CCL-2, IL-6 and IL-8 levels in cell culture supernatant after treatment with PBA before and after co-culture with macrophages. Significance is depicted as follows: * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001.