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. 2022 Jan 8;12(1):101. doi: 10.3390/biom12010101

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of CX-01 treatment on complement hemolytic activity and complement consumption in the rat model of TH. (A) The hemolytic activity (CH50) of sera was measured, and the CH50 at each time point was normalized to the baseline level, which was pre-blast injury and the percentages of normalization are shown; (B) C1q blood serum concentrations; and (C) C3 blood serum concentrations. Data are presented as mean ± SEM. The individual time points were compared using the unpaired t-test with Welch’s correction, and comparison of the groups was performed by two-way ANOVA. * = p < 0.05 Labels: B + H = blast + hemorrhagic shock; CX-01—treated injured rats (more details in Figure 4A).