TABLE 2.

MICs of the six drugs against the 19 different species of dermatophytes

Species (no. of isolates)	Antifungal agent	MIC (μg/ml)
		Range	Geometric mean	MIC50	MIC90
M. canis (6)	Voriconazole	0.25–0.5	0.40	0.5	0.5
	Itraconazole	0.03–1	0.10	0.06	0.125
	Terbinafine	0.03–2	0.06	0.01	0.06
	Fluconazole	2–64	10.07	8	16
	Ketoconazole	0.5–4	1.122	1	1
	Griseofulvin	0.25–1	0.561	0.5	1
M. gypseum (6)	Voriconazole	0.25–2	1	1	2
	Itraconazole	0.03–0.06	0.04	0.03	0.06
	Terbinafine	<0.04–0.06	0.01	0.007	0.03
	Fluconazole	16–64	28.51	32	32
	Ketoconazole	1–2	1.78	2	2
	Griseofulvin	0.5–1	0.63	0.5	1
M. cookei (1)	Voriconazole	0.5
	Itraconazole	0.5
	Terbinafine	<0.04
	Fluconazole	0.5
	Ketoconazole	1
	Griseofulvin	0.5
M. persicolor (1)	Voriconazole	0.5
	Itraconazole	0.5
	Terbinafine	0.25
	Fluconazole	16
	Ketoconazole	2
	Griseofulvin	2
M. ferrugineum (1)	Voriconazole	0.5
	Itraconazole	0.5
	Terbinafine	1
	Fluconazole	0.125
	Ketoconazole	2
	Griseofulvin	2
M. distortum (1)	Voriconazole	0.5
	Itraconazole	0.06
	Terbinafine	0.01
	Fluconazole	32
	Ketoconazole	2
	Griseofulvin	1
M. audouinii (2)	Voriconazole	0.5–2	1
	Itraconazole	0.25	0.25
	Terbinafine	0.007–0.06	0.02
	Fluconazole	64–>64	64
	Ketoconazole	1–2	1.41
	Griseofulvin	0.5–1	0.71
M. nanum (2)	Voriconazole	<0.125–0.25	0.18
	Itraconazole	0.03	0.03
	Terbinafine	0.125–0.01	0.03
	Fluconazole	4	4
	Ketoconazole	0.5–1	0.71
	Griseofulvin	4–8	5.66
T. mentagrophytes (23)	Voriconazole	<0.125–1	0.46	0.5	1
	Itraconazole	<0.015–2	0.04	0.03	0.125
	Terbinafine	<0.004–0.125	0.02	0.01	0.06
	Fluconazole	1–>64	19.39	16	64
	Ketoconazole	0.5–16	1.55	1	4
	Griseofulvin	0.125–8	1.16	1	4
T. rubrum (27)	Voriconazole	<0.125–1	0.38	0.5	0.5
	Itraconazole	0.03–1	0.08	0.06	0.25
	Terbinafine	<0.04–0.25	0.01	0.007	0.01
	Fluconazole	2–8	3.31	4	8
	Ketoconazole	0.125–2	0.47	0.5	1
	Griseofulvin	0.5–8	1.95	2	4
T. erinacei (1)	Voriconazole	0.25
	Itraconazole	0.25
	Terbinafine	0.01
	Fluconazole	64
	Ketoconazole	16
	Griseofulvin	2
T. raubistchekii (1)	Voriconazole	0.25
	Itraconazole	0.5
	Terbinafine	0.007
	Fluconazole	2
	Ketoconazole	1
	Griseofulvin	2
T. verrucosum (4)	Voriconazole	0.5–>64	2.83	1	64
	Itraconazole	0.125–>8	0.35	0.125	8
	Terbinafine	0.06–>2	0.25	0.125	2
	Fluconazole	>64	64	64	64
	Ketoconazole	2–16	6.72	4	16
	Griseofulvin	2–8	5.66	8	8
T. terrestre (1)	Voriconazole	2
	Itraconazole	0.5
	Terbinafine	0.01
	Fluconazole	64
	Ketoconazole	2
	Griseofulvin	>8
T. megninii (1)	Voriconazole	2
	Itraconazole	0.5
	Terbinafine	0.01
	Fluconazole	0.5
	Ketoconazole	0.25
	Griseofulvin	1
T. soudanense (2)	Voriconazole	0.25–0.5	0.35
	Itraconazole	0.06–0.125	0.09
	Terbinafine	0.01–0.06	0.02
	Fluconazole	64–>64	64
	Ketoconazole	16–>16	16
	Griseofulvin	8–>8	8
T. tonsurans (7)	Voriconazole	0.25–1	0.67	0.5	1
	Itraconazole	0.03–1	0.15	0.06	0.5
	Terbinafine	0.007–0.25	0.04	0.01	0.125
	Fluconazole	64–>64	64	64	64
	Ketoconazole	1–8	2.97	2	8
	Griseofulvin	1–8	2.44	2	4
T. equinum (3)	Voriconazole	0.25–0.5	0.40
	Itraconazole	0.03–0.06	0.04
	Terbinafine	0.01–0.03	0.02
	Fluconazole	64–>64	64
	Ketoconazole	4–8	6.35
	Griseofulvin	8	8
E. floccosum (10)	Voriconazole	0.25–1	0.5	0.5	1
	Itraconazole	<0.015–0.06	0.11	0.125	0.5
	Terbinafine	0.01–0.25	0.02	0.01	0.06
	Fluconazole	0.5–4	2.46	2	4
	Ketoconazole	0.25–1	0.61	0.5	1
	Griseofulvin	0.25–1	0.47	0.5	1