The role of lea-1 in worm stress resistance: wild-type N2 and daf-2(e1370) mutants with lea-1 knockdown subjected to (A) osmotic stress, 500 mM NaCl; (B) heat stress, 40 °C; (C) UV stress (254 nm, 200 J/m2), and (D) oxidative stress, 0.28% tert-butyl hydroperoxide (TBHP). Survival curves in (A,C) represent pooled data from two and three independent experiments, respectively. Error bars in (B,D) indicate SEM of three independent trials. Survival data of all the stress assays are summarized in Tables S3–S6. EV—empty vector control. ns: p > 0.05, ** p ≤ 0.01 (RNAi*strain interaction, two-way ANOVA).