. 2022 Jan 13;10(1):169. doi: 10.3390/biomedicines10010169

Table 2.

Correlations between CSF biomarkers, plasma biomarkers, and neuroimaging data.

Molecules	CSF Biomarkers				Plasma Biomarkers		Combination Biomarkers		Neuroimaging Data
Molecules	NFL	Aβ_1–42	t-Tau	p-Tau₁₈₁	NFL	Aβ_1–42	CSFNFL/Aβ_1–42	PlasmaNFL/Aβ_1–42	Aβ− PET (SUVR)	Hippocampal Volume/ICV	Entorhinal Thickness
CSF NFL concentrations	1	−0.259 **	0.486 *	0.502 *	0.608 *	−0.110	0.710 *	0.521 *	0.334 *	−0.359 **	−0.194 **
CSF Aβ_1–42 concentrations		1	−0.410 *	−0.357 *	−0.242 **	0.472 *	−0.736 *	−0.462 *	−0.701 *	0.340 *	0.245 *
CSF t-Tau concentrations			1	0.923 *	0.265 **	−0.305 *	0.491 *	0.382 *	0.617 *	−0.427 *	−0.378 *
CSF p-Tau₁₈₁ concentrations				1	0.280 **	−0.304*	0.476 *	0.364 *	0.555 *	−0.392 *	−0.334 *
Plasma NFL concentrations					1	0.169 **	0.493 *	0.612 *	0.218 **	−0.432 *	−0.221 **
Plasma Aβ_1–42 concentrations						1	−0.321 *	−0.503 *	−0.374 *	0.086	0.031
CSF NFL/Aβ_1–42 ratio							1	0.562 *	0.580 *	−0.379 *	−0.213 **
Plasma NFL/Aβ_1–42 ratio								1	0.410 *	−0.409 *	−0.132
Aβ− PET (SUVR score)									1	−0.348 *	−0.307 *
Hippocampal volume/ICV										1	0.622 *
Entorhinal thickness											1

Data are presented as Pearson’s correlation coefficient (r). Bold values indicate significant associations (*, p <0.001; **, p <0.01). Abbreviations: Aβ, amyloid-beta protein; t-Tau, total Tau protein; p-Tau, phosphorylated Tau protein; NFL, neurofilament light chain; ICV, Intracranial volume; SUVR, standardized uptake value ratio; CSF, cerebrospinal fluid.