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. 2022 Jan 5;12(1):80. doi: 10.3390/biom12010080

Figure 1.

Figure 1

Compounds 1 and 2 (4,5-dichloro-imidazolate-1yl-gold(I)-triphenylphosphane and 4,5-dicyano-imidazolate-1y-gold(I)-triphenylphosphane, respectively) suppressed breast cancer growth in vivo. FVB female mice were injected with syngeneic A17 TNBC cells and treated with cisplatin, compound 1 or 2, or isotonic solution. Treatment schedule (q3 × 4) started ten days after cell injection. (A) Tumor growth curves. Values are mean ± SEM, (5 mice/group). (B) Representative images of tumors explanted from control and treated mice at sacrifice (upper panel) and relative tumor weight (lower panel) 24 days after tumor challenge; values are mean ± SEM. The significance was determined by the one-way ANOVA test followed by Tukey’s multiple comparison post-test; each group was compared to control (* p < 0.05; *** p < 0.001). (C) Gold and platinum content in kidneys of mice treated with compound 1, compound 2, or cisplatin evaluated by inductively coupled plasma mass spectrometry (ICP-MS). The data are presented as micrograms of metal (Au or Pt) per gram of tissue. Values are mean ± SEM. The significance was determined by the one-way ANOVA test followed by Tukey’s multiple comparison test (*** p < 0.001) (modified from [38]).