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The interplay between αS and lipid biology in synucleinopathies—possible scenarios. (A) αS imbalance is upstream of abnormal lipid alterations. (B) Lipid imbalance is upstream of abnormal αS alterations. (C) αS imbalance and lipid imbalance influence and reinforce each other. (D) Primary lipid imbalance and αS-induced lipid imbalance are additive. αS, α-synuclein; FA, fatty acid; DG, diacylglycerol.
