Table 3.
Univariate and multivariate analyses of prognostic factors for overall survival.
| Factors | Univariate p-Value |
Multivariate | ||
|---|---|---|---|---|
| HR | 95% CI | p-Value | ||
| Age (<74 vs. ≥74 years) | 0.302 | |||
| Sex (male vs. female) | 0.279 | |||
| Etiology (NBNC vs. viral) | 0.010 | 0.605 | 0.380–0.962 | 0.034 |
| History of non-systemic treatment (with vs. without) | 0.981 | |||
| mALBI grade (1/2a vs. 2b) | <0.005 | 0.409 | 0.249–0.674 | <0.005 |
| Macroscopic vascular invasion (absent vs. present) | <0.005 | 0.838 | 0.320–1.129 | 0.113 |
| Extrahepatic metastasis (absent vs. present) | 0.010 | 0.601 | 0.456–1.199 | 0.221 |
| Relative tumor volume (<50% vs. ≥50%) | <0.005 | 0.740 | 0.377–1.866 | 0.666 |
| Serum AFP value (<400 vs. ≥400), ng/mL | <0.005 | 0.409 | 0.251–0.667 | <0.005 |
| Serum DCP value (<174 vs. ≥174), ng/mL | 0.133 | |||
| Initial objective response by RECIST (OR vs. non-OR) | 0.007 | 0.369 | 0.197–0.691 | <0.005 |
| Age (<74 vs. ≥74 years) | 0.302 | |||
| Sex (male vs. female) | 0.279 | |||
| Etiology (NBNC vs. viral) | 0.010 | 0.662 | 0.416–1.055 | 0.083 |
| History of non-systemic treatment (with vs. without) | 0.981 | |||
| mALBI grade (1/2a vs. 2b) | <0.005 | 0.451 | 0.277–0.734 | <0.005 |
| Macroscopic vascular invasion (absent vs. present) | <0.005 | 0.861 | 0.437–1.697 | 0.666 |
| Extrahepatic metastasis (absent vs. present) | 0.010 | 0.786 | 0.484–1.278 | 0.332 |
| Relative tumor volume (<50% vs. ≥50%) | <0.005 | 0.488 | 0.215–1.111 | 0.087 |
| Serum AFP value (<400 vs. ≥400), ng/mL | <0.005 | 0.359 | 0.221–0.583 | <0.005 |
| Serum DCP value (<174 vs. ≥174), ng/mL | 0.133 | |||
| Initial objective response by mRECIST (OR vs. non-OR) | <0.005 | 0.378 | 0.234–0.611 | <0.005 |
NBNC, non-B-non-C viral hepatitis; mALBI, modified albumin–bilirubin; AFP, alpha-fetoprotein; DCP, des-γ-carboxy prothrombin; RECIST, Response Evaluation Criteria in Solid Tumors; mRECIST, modified Response Evaluation Criteria in Solid Tumors; OR, objective response.