Figure 1.

¹⁸⁸ReO₄ IC50 dose finding on Huh7 and HepG2 cell lines. Huh7 cells viability was measured using LIVE/DEAD^® Viability/Cytotoxicity Kit and the mean viability of untreated cells (control group), and the treated groups were compared on various doses of 18, 37, and 55 MBq of ¹⁸⁸ReO₄ at 18, 24, and 48 h post-exposure for finding the effective dose of ¹⁸⁸ReO₄ (A–C). HepG2 cells viability was measured using LIVE/DEAD^® Viability/Cytotoxicity Kit in response to 37, 55, and 73 MBq of ¹⁸⁸ReO₄ 18, 24, and 48 h post-exposure for finding the effective dose of ¹⁸⁸ReO4 in treated HepG2 cells (D–F). The IC50 value of 188ReO₄ in Huh7 cells was 37 MBq 24 h after exposure, and it was 55 MBq 48 h for HepG2 cells. Data are presented as the mean ± SD, n = 3 (* p < 0.05, ** p < 0.01, and *** p < 0.001, **** p < 0.0001).