Figure 1.

Biodistribution of AAV2 vector in the TGFα/c-myc HCC mouse model. Tumor-bearing animals injected intravenously with scAAV2.SFFV.Fluc and scAAV2.CMV.eGFP. Vector dose: 2 × 10¹¹ particles per vector per animal. Relative vector genomes were quantified by qPCR 96 h after the first vector (scAAV2.SFFV.Fluc) administration. The levels of firefly luciferase transgene were normalized to ng DNA. Data are shown in log₁₀-scale and as the mean target-to-reference ratio per animal with mean and SD. Statistics: Cohort sizes account for Shapiro–Wilk normality test (p ≤ 0.0459). Shapiro–Wilk normality test with log₁₀-transformed data (p = 0.0209); Kruskal–Wallis test (p < 0.0001) and Dunn’s test ** p < 0.01, **** p < 0.0001). N = 8 animals.